Right now, the highways are packed, and airports are crowded with people trying to get home for the holidays.
The weather this year is adding an extra layer of complications to an already stressful situation.
In California, a bomb cycle shut I-80 down for several hours Tuesday night, with feet of snow falling across the high Sierra Nevada Mountains. It's just one of several storms that could impact holiday travel plans this week.
Denver's weather on Thanksgiving will be cold. Temperatures in the teens in the morning will only warm into the upper 30s by the afternoon. Mostly cloudy skies, with dry weather through the evening.
Elsewhere across the country, a departing storm leaving the northeast could lead to widespread airport delays from Washington D.C. through Boston. As the rain tapers off early on Thanksgiving, wind is expected to be quite significant throughout the day.
In the southeast, dry and windy weather is in the forecast. Mild weather for Atlanta with highs in the 60s. Miami will be warm and sunny, with 80s for highs.
Another system will bring a mix of rain and snow from California up through Utah and Wyoming. Airports in this part of the country have a higher likelihood of seeing weather related delays on Turkey Day than some other areas.
In the Pacific Northwest, most areas will be dry. Snow will be possible in the mountains of Oregon and Washington, with snow showers also possible over parts of Idaho and northern California.
You can find more details on our First Alert 5 weather app. On our app, you can customize your location to see such things as the local radar, weather alerts and both hourly and 10 day forecast.